Treatment & Management


TREATMENT OF TRICHURIASIS

1.Mebendazole
2.Albendazole


MEBENDAZOLE

Modes of Action: Mebendazole inhibits the formation of the worms’ microtubules and causes the worms’ glucose depletion.

Mebendazole tablets are indicated for the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

Efficacy varies as a function of such factors as pre-existing diarrhea and gastrointestinal transit time, degree of infection, and helminth strains. Efficacy rates derived from various studies are shown in the table below:

Pinworm (enterobiasis)
Whipworm (trichuriasis)
Common Roundworm (ascariasis)
Hookworm
Cure rates mean
95%
68%
98%
96%
Egg reduction mean
—
93%
99%
99%
*200 to 400 mg po tid for 3 days and then 400 to 500 mg tid for 10 days



ALBENDAZOLE

            ALBENZA (albendazole) is an orally administered broad-spectrum anthelmintic. Chemically, it is methyl 5-(propylthio)-2-benzimidazolecarbamate. Albendazole act by creases whipworm ATP production, causing energy depletion, immobilization, and death. 400 mg bid for 8 to 14 days may be used.



MANAGEMENT OF TRICHURIASIS


Supportive treatment :

  • IV FLUID for resuscitation (use 14-16G needle)- Crystalloid (0.9% saline or Ringers Lactate)
    • IV Fluid
  • BLOOD TRANSFUSION – Packed RBC (Cross matched+warmed at 37C
packed RBC



    platelet
    caryoprecipitate
  • DIVC Regime – Fresh Frozen Plasma units,Platelets units and Cryoprecipitate
    • fresh frozen plasma


























Refrences                                                                                                                                   

1. http://water.ygoy.com/trichuriasis-%E2%80%93-diagnosis-and-treatment/
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